Technology Background of our Chairman
Lew C. Schon, MD, FACS, our Chairman has been an active researcher in the therapeutic uses of stem cells and growth factors in orthopedic surgery. He has been the principal or co-principal investigator on numerous grants and is well-published in the field.
Lew C. Schon, MD, FACS – Recent funded research in the arena of orthobiologics and specifically, stem cells and growth factors
1. Schon (PI) 6/09- 12/10
High Density Nanofilms for Orthopaedic Therapies
The objective is to develop nanofilms with specific affinity to stem or other biological cells of interest for in-surgery application to a wide array of prosthetic implants as well as to bone grafts.
Sponsor: 2009 Maryland Nanobiotechnology Research and Industry Competition Grants – Maryland DBED
Role: Primary Investigator
2. Schon (Co-Investigator) 4/08- 4/09
Bone and tendon healing mechanisms of mesenchymal stem cells and hematopoetic progenitors derived from human adult bone marrow
The objective is to define the role of hmsc and hhsc in healing tendinopathy and bone non-unions. By identifying the molecular mediators more effective treatments can be established
Sponsor: Maryland Stem Cell Research Fund
Role: Co-Investigator
3. Schon (PI) 4/05/07 -5/01/08
Quantitative and Qualitative Description: Effects of Bone Marrow Derived Growth Factors and Cytokines on Autogenous Mesenchymal Stem Cells of Various Aspiration Sites
The objective is to advance the understanding of the molecular mechanisms of the acceleration of bone healing by growth factors and cytokines from bone marrow derived platelet rich plasma (PRP) and mesenchymal stem cells from bone marrow aspirate.
Sponsor: AOFAS
Role: Primary Investigator
4. Schon (P) 7/01/06 – 7/01/08
Inflammatory cytokine expression in degenerative tendinosis: quantitative description and relation to whole-tendon mechanical stimuli
The objectives of this study are designed to characterize gene expression in matched pairs of normal and disease tendon tissue and study tenocyte cell responsiveness to treatment with specific growth factors.
Sponsors – AOFAS, Medstar Research Institute
Role: Primary Investigator
5. Schon (PI) 7/01/07 – 7/01/08
In Vitro Response of Normal and Diseased Tenocytes to PDGF-BB
To characterize the differential response among injured tendons to PDGF-BB.
Sponsor – Biomimetics
Role: Primary Investigator
6. Schon (co-PI) 7/01/06 – 12/22/08
The effect of rh PDGF in foot and ankle Fusions: a pivotal FDA clinical trial
This is a randomized prospective multicenter surgical trial comparing rh pdgf vs autograft bone as an adjuvant for hindfoot and ankle fusions
Sponsors – Biomimetics
Role: Co- Investigator
Lew C. Schon, MD, FACS - Selected Peer-Reviewed Publications (in chronological order from total 88 journal articles, multiple book chapters, and more than 90 abstracts).
Han S-H, Lee JW, Guyton GP, Parks BG, Courneya JP, Schon LC. Effect of extracorporeal shock wave therapy on cultured tenocytes. Foot Ankle Int 2009;30(2):93-8. Winner of the 2008 AOFAS Goldner Award for Best Basic Science Paper.
Scherb MB, Han S-H, Courneya JP, Guyton GP, Schon LC. Effect of bupivacaine on cultured tenocytes. Orthopedics 2009 Jan;32(1):26.
League AC, Parks BG, Schon LC. Radiographic and pedobarographic comparison of femoral head allograft versus block plate with dorsal opening wedge medial cuneiform osteotomy: a biomechanical study. Foot Ankle Int 2008 Sep;29(9):922-6.
Kirk KL, Schon LC. Technique tip: periosteal flap augmentation of the Brostrom lateral ankle reconstruction. Foot Ankle Int 2008 Feb;29(2):254-5.
Jung HG, Myerson MS, Schon LC. Spectrum of operative treatments and clinical outcomes for atraumatic osteoarthritis of the tarsometatarsal joints. Foot Ankle Int 2007 Apr;28(4):482-9.
Baumhauer JF, O'Keefe RJ, Schon LC, Pinzur MS. Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study. Foot Ankle Int 2006 Oct;27(10):797-800.
Chodos MC, Schon LC. Osteochondral lesions of the talus: current treatment modalities and future possibilities. Curr Opin Orthop 2006 Mar;17:111-6.
Vora AM, Tien TR, Parks BG, Schon LC. Correction of moderate and severe acquired flexible flatfoot with medializing calcaneal osteotomy and flexor digitorum longus transfer. J Bone Joint Surg Am 2006 Aug;88(8):1726-34.
Lau Johnny T C; Stamatis Emmanouil D; Myerson Mark S; Schon Lew C Implantable direct-current bone stimulators in high-risk and revision foot and ankle surgery: a retrospective analysis with outcome assessment. American journal of orthopedics (Belle Mead, N.J.) 2007;36(7):354-7.
Giza Eric; Cush Gerard; Schon Lew C The flexible flatfoot in the adult. Foot and ankle clinics 2007;12(2):251-71.
Jung Hong Geun; Myerson Mark S; Schon Lew C Spectrum of operative treatments and clinical outcomes for atraumatic osteoarthritis of the tarsometatarsal joints. Foot & ankle international 2007;28(4):482-9.
Benthien Ross A; Parks Brent G; Guyton Gregory P; Schon Lew C Lateral column calcaneal lengthening, flexor digitorum longus transfer, and opening wedge medial cuneiform osteotomy for flexible flatfoot: a biomechanical study. Foot & ankle international 2007;28(1):70-7.
Baumhauer Judith F; O'Keefe Regis J; Schon Lew C; Pinzur Michael S Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study. Foot & ankle international 2006;27(10):797-800.
Vora AM, Tien TR, Parks BG, Schon LC. Correction of moderate and severe acquired flexible flatfoot with medializing calcaneal osteotomy and flexor digitorum longus transfer, J Bone Joint Surg AM, 2006, 88(8), 1726-34, 2006
Cohen DA, Parks BG, Schon LC. Screw fixation compared to H-locking plate fixation for first metatarsocuneiform arthrodesis: a biomechanical study, Foot Ankle Int. 2005 Nov;26(11):984-9.
Rosenfeld JF, Parks BG, Schon LC, Biomechanical investigation of optimal fixation of isolated talonavicular joint fusion, Am J Orthop. 2005 Sep;34(9):445-8
Sharma KM, Parks BG, Nguyen A, Schon LC, Plantar-to-dorsal compared to dorsal-to-plantar screw fixation for proximal chevron osteotomy: a biomechanical analysis, Foot Ankle Int. 2005 Oct;26(10):854-.
Jung HG, Zaret DI, Parks BG, Schon LC. Effect of first metatarsal shortening and dorsiflexion osteotomies on forefoot plantar pressure in a cadaver model, Foot Ankle Int. 2005 Sep;26(9):748-53
Jung HG, Guyton GP, Parks BG, Title CI, Dom KJ, Nguyen A, Schon LC, Supplementary axial Kirschner wire fixation for crescentic and Ludloff proximal metatarsal osteotomies: a biomechanical study, Foot Ankle Int. 2005 Aug;26(8):620-6.
Schon LC, Dom KJ, Jung HG, Clinical tip: stabilization of the proximal Ludloff osteotomy, Foot Ankle Int. 2005 Jul;26(7):579-81.
Sanders AP, Weijers RE, Snijders CJ, Schon LC., Three-dimensional reconstruction of magnetic resonance images of a displaced flexor hallucis longus tendon in hallux valgus, J Am Podiatr Med Assoc. 2005 Jul-Aug;95(4):401-4.
Lau JT, Mahomed NM, Schon LC. Results of an Internet Survey Determining the Most Frequently Used Ankle Scores by AOFAS Members. Foot Ankle Int 2005; 26(6):479-82.
Title CI, Jung HG, Parks BG, Schon LC. The peroneal groove deepening procedure: a biomechanical study of pressure reduction. Foot Ankle Int 2005; 26(6):442-8.
Jung H-G, Zaret D, Parks BG, Schon LC. Effect of first metatarsal shortenings and dorsiflexion osteotomies on forefoot plantar pressure in a cadaveric model. Foot Ankle Int 2005; 26(9):748-53.
Rosenfeld JF, Parks BG, Schon LC. Biomechanical investigation of optimal fixation of isolated talonavicular joint fusion. Am J Orthop 2005 Sep; 34(5):445-8.
Sanders AP, Weijers RE, Snijders CJ, Schon LC. Three-dimensional reconstruction of magnetic resonance images of a displaced flexor hallucis longus tendon in hallux valgus. J Am Pod Med Assoc 2005 Jul; 95(4):401-4.
Schon LC, Dom KJ, Jung H-G. Technique tip: stabilization of the proximal Ludloff osteotomy. Foot Ankle Int 2005 Jul; 26(7):579-81.
Schon LC, Herbst SA. Tendon ruptures and lacerations. In: Calhoun JH, Laughlin RT, editors. Fractures of the Foot and Ankle: Diagnosis and Treatment of Injury and Disease.Boca Raton: Taylor & Francis; 2005. p. 319-44.
Sharma KM, Parks BG, Nguyen A, Schon LC. Plantar-to-dorsal compared to dorsal-to-plantar screw fixation for proximal chevron osteotomy: a biomechanical analysis. Foot Ankle Int 2005 Oct; 26(10):854-8.
Schon LC. Salvage of failed heel pain surgery. In: Nunley JA, Pfeffer GB, Sanders RW, Trepman E., editors. Advanced Reconstruction: Foot and Ankle.Rosemont, IL: American Association of Orthopaedic Surgeons; 2004. p. 349-52.
Schon LC. Midfoot Charcot reconstruction: chronic rockerbottom reconstruction. In: Nunley JA, Pfeffer GB, Sanders RW, Trepman E, editors. Advanced Reconstruction: Foot and Ankle.Rosemont, IL: American Association of Orthopaedic Surgeons; 2004. p. 411-6.
Chiodo CP, Schon LC, Myerson MS: Clinical results with the Ludloff osteotomy for correction of adult hallux valgus. Foot Ankle Int 2004; 25:532-536.
Lau JTC, Stamatis ED, Parks BG, Schon LC: Modifications of the Weil osteotomy have no effect on plantar pressure. Clin Orthop 2005; 421:194-198.
Key Management Personnel
Richard Spedden, SM, MBA, PE - CEO & Tech Innovation
Laura J. Pingel, MS - CFO & Operations